Corneal Regeneration by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030013042
Publisher: Springer International Publishing

17.2.2 Extraocular MSCs in Experimental Models of Corneal Epithelial Damage

17.2.2.1 Experimental Models of Corneal Epithelial Damage

In order to study different potential therapies to treat diseases, it is necessary to deepen in the knowledge and the understanding of diseases. Experimental models represent one of the best tools that help to accomplish this goal.

There are a lot of different kinds of experimental models of corneal epithelial damage with diverse characteristics, such as the size of the affected area in the cornea and/or the limbus, the severity of the model, and the methodology used to develop it, among others. Experimental models with central corneal damage but without limbal injury are considered corneal burn or corneal injury models. Corneal burn models are induced by a chemical agent, whereas corneal injury is induced by mechanical damage. Experimental models that include limbal damage are designated as LSCD models. The most used agent during the induction of both corneal burn and LSCD models is sodium hydroxide (NaOH). However, ethanol, n-heptanol, and mechanical scraping have been also used to induce corneal epithelial damage.

There are several studies that describe the use of MSCs to treat corneal epithelial injuries using different experimental models and methodology. One of the principal factors that could condition the results of these works is the administration route: systemically (intravenous or intraperitoneal), using different carriers (amniotic membrane, fibrin, biopolymers, etc.), topically, or even by subconjunctival injection. In addition, some researchers have studied the therapeutic effect of endogenous MSCs in the ocular surface after induced corneal epithelial damage.

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